Inpact Outputs
IMPACT – video
PvD1 – video
• Paper “Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells” (2015) J. Peptide Science, 21, 178–185.
http://onlinelibrary.wiley.com/doi/10.1002/psc.2741/epdf
Miguel Castanho (IMM) was awarded by the European Peptide Society with the Zervas Award for achievements in Peptide Science. In this occasion the editor or Journal of Peptide Science has invited M. Castanho to write an overview of the state of the art and prospects for the future. INPACT is a multidisciplinary project using state of the art methodologies, therefore an example of the modern trend in peptide drug development.
• Paper “Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection.” (2015) FEBS J., 282, 2267-2278.
http://onlinelibrary.wiley.com/doi/10.1111/febs.13274/epdf
Viruses are dynamic molecular assemblies optimized to invade cells. Capsid proteins in particular are multifunctional proteins that may intervene in cellular membrane translocation and intracellular trafficking. Therefore, they are perfect sources for drug vectors able to transverse cell membranes and epithelia. The relevance of this hypothesis to INPACT is two-fold: cationic peptides derived from viral capsid proteins are good candidates to target the anionic membranes of bacteria, and trafficking properties of selected domains of the protein may be efficient in crossing the blood-brain barrier.
• Paper “Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism” (2017) ACS Chemical Biology, accepted.
http://pubs.acs.org/doi/abs/10.1021/acschembio.7b00087
Two peptides able to cross reversibly the Blood-brain barrier have been identified. These peptides are able to transport in and out the Central Nervous System therapeutic proteins.
• Paper “Antibody Approaches To Treat Brain Diseases” Trends in Biotechnology (2016) 34 (1) 36–48 (Collaborative between IMM and Technophage)
http://www.sciencedirect.com/science/article/pii/S0167779915002231
• Book (training): “Integrative Human Biochemistry. A Textbook for Medical Biochemistry” Springer (New York, USA), 2015 (Collaborative between IMM and UFRJ)
http://www.springer.com/it/book/9781493930579
INPACT enabled that an old (but never implemented) project of IMM and UFRJ became reality: a new textbook with a new pedagogical approach to the training in medical biochemistry, with world-wide distribution.
This outcome will be important in the training of future scientists and health care practitioners, taking the legacy of INPACT far beyond the period of the project itself.
- Patent WO/2016/120843, PCT/IB2016/050467 “ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER’S DISEASE AND RELATED DISORDERS”, https://patentscope.wipo.int/search/docservicepdf_pct/id00000034395600/PAMPH/WO2016120843.pdf
• Outreaching paper (in Portuguese) “Planeta Azul: Quando o Sol ilumina Céu e Mar”, Ciência Hoje (2015) 329, 18-23 (Collaborative between IMM and Ciência Hoje)
http://www.cienciahoje.org.br/noticia/v/ler/id/3749/n/planeta_azul:_quando_o_sol_ilumina_ceu_e_mar
